Peripheral Spexin Inhibited Food Intake in Mice
نویسندگان
چکیده
منابع مشابه
Food intake is inhibited by oral oleoylethanolamide.
Oleoylethanolamide (OEA) may be an endogenous regulator of food intake, and intraperitoneal injection of this compound decreases food intake in 24 h-starved rats. It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract, thereby preventing its use as an oral antiobesity compound. We now show that oral OEA inhibits food intake dose dependently a...
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Histidine is an amino acid precursor of neuronal histamine. It is evident that peripheral injection of histidine produces effects that resemble to centrally administered histamine. The aim of the present study was to compare the effects of intracerebroventricular (ICV) injection of histamine and inraperitoneal (IP) injection of histidine on food intake in rabbits. ICV injections of histamine (1...
متن کاملCentral effect of histamine and peripheral effect of histidine on food intake in rabbits
Histidine is an amino acid precursor of neuronal histamine. It is evident that peripheral injection of histidine produces effects that resemble to centrally administered histamine. The aim of the present study was to compare the effects of intracerebroventricular (ICV) injection of histamine and inraperitoneal (IP) injection of histidine on food intake in rabbits. ICV injections of histamine (1...
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Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are cosecreted from the intestine in response to nutrient ingestion. Peripheral administration of GLP-1 or PYY decreases food intake (FI) in rodents and humans; however, the exact mechanisms by which these peptides regulate FI remain unclear. Male C57BL/6 mice were injected (ip) with exendin-4 (Ex4, a GLP-1 receptor agonist) and/or PYY (0.03–...
متن کاملEffect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.
Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are satiation factors secreted by the small intestine in response to lipid meals. Apo AIV and CCK-8 has an additive effect to suppress food intake relative to apo AIV or CCK-8 alone. In this study, we determined whether CCK-8 (1, 3, or 5 μg/kg ip) reduces food intake in fasted apo AIV knockout (KO) mice as effectively as in fasted wild-type...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2020
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2020/4913785